Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer

Fangyuan Chen; Sayali Onkar; Jian Zou; Yujia Li; Haley Arbore; Sai Maley; George Tseng; Peter C Lucas; Tullia C Bruno; Dario A A Vignali; Julia Foldi; Marija Balic; Adrian V Lee; Steffi Oesterreich

doi:10.1038/s41698-024-00746-z

Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer

NPJ Precis Oncol. 2024 Nov 9;8(1):257. doi: 10.1038/s41698-024-00746-z.

Authors

Fangyuan Chen¹, Sayali Onkar^{2

3}, Jian Zou⁴, Yujia Li⁴, Haley Arbore^{3

5}, Sai Maley⁶, George Tseng⁴, Peter C Lucas^{3

6

7

8}, Tullia C Bruno^{2

3}, Dario A A Vignali², Julia Foldi³, Marija Balic³, Adrian V Lee^{9

10}, Steffi Oesterreich^{11

12

13}

Affiliations

¹ Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
² Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
³ UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
⁴ Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
⁵ Interdisciplinary Biomedical Graduate Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
⁶ National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA.
⁷ Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
⁸ Cancer Biology Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
⁹ Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. [email protected].
¹⁰ Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA. [email protected].
¹¹ Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. [email protected].
¹² Cancer Biology Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. [email protected].
¹³ Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA. [email protected].

Abstract

Understanding interplay of breast cancer and microenvironment is critical. Here we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER + /HER2- ILCs. We found proliferative subtype associated with increased suppressive immune infiltration, and defined a signature associated with lower proliferative, pro-inflammatory TAM infiltration, and improved survival in ER+ breast cancer. Our work identified genes related to ILC immune microenvironment and prognosis.

Abstract

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