CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

Mol Neurodegener. 2024 Nov 11;19(1):82. doi: 10.1186/s13024-024-00767-z.

Abstract

This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical progression to AD with high accuracy; some of these CSF proteins related to immune function, neurotrophic processes, energy metabolism and endolysosomal functioning (e.g., ITGB2, CLEC5A, IGFBP-1, CST3) changed before amyloid positivity is established.

Publication types

  • Letter

MeSH terms

  • Aged
  • Alzheimer Disease* / cerebrospinal fluid
  • Alzheimer Disease* / metabolism
  • Biomarkers* / cerebrospinal fluid
  • Disease Progression*
  • Female
  • Humans
  • Inflammation / metabolism
  • Male
  • Middle Aged
  • Proteolysis
  • Proteome / metabolism

Substances

  • Biomarkers
  • Proteome