Some assembly required: a single-RNA vaccine against enterovirus-D68

Noah Pollack; William T Jackson

doi:10.1016/j.tips.2024.10.010

Some assembly required: a single-RNA vaccine against enterovirus-D68

Trends Pharmacol Sci. 2024 Dec;45(12):1089-1091. doi: 10.1016/j.tips.2024.10.010. Epub 2024 Nov 11.

Authors

Noah Pollack¹, William T Jackson²

Affiliations

¹ Department of Microbiology and Immunology and Center for Pathogen Research, University of Maryland School of Medicine, 685 W. Baltimore Avenue, Baltimore, MD 21201, USA.
² Department of Microbiology and Immunology and Center for Pathogen Research, University of Maryland School of Medicine, 685 W. Baltimore Avenue, Baltimore, MD 21201, USA. Electronic address: [email protected].

PMID: 39532602
PMCID: PMC11624984 (available on 2025-12-01)
DOI: 10.1016/j.tips.2024.10.010

Abstract

A single-RNA-based vaccine against enterovirus-D68, a respiratory virus and causative agent of severe paralytic disease in children, by the Erasmus group shows great promise in generating broadly cross-neutralizing antibodies in mice and macaque models of infection.

Keywords: RNA vaccine; acute flaccid myelitis; enterovirus D68; virus-like particles.

MeSH terms

Animals
Antibodies, Neutralizing / immunology
Enterovirus D, Human* / immunology
Enterovirus Infections* / immunology
Enterovirus Infections* / prevention & control
Enterovirus Infections* / virology
Humans
Mice
Viral Vaccines* / immunology
mRNA Vaccines

Substances

Viral Vaccines
Antibodies, Neutralizing
mRNA Vaccines

Abstract

MeSH terms

Substances

Grants and funding