Prussian blue nanocages as efficient radical scavengers and photothermal agents for reducing amyloid-beta induced neurotoxicity

Ting Wu; Xining Zhang; Shuangfei Cai; Wei Zhang; Rong Yang

doi:10.1016/j.colsurfb.2024.114369

Prussian blue nanocages as efficient radical scavengers and photothermal agents for reducing amyloid-beta induced neurotoxicity

Colloids Surf B Biointerfaces. 2025 Feb:246:114369. doi: 10.1016/j.colsurfb.2024.114369. Epub 2024 Nov 7.

Authors

Ting Wu¹, Xining Zhang², Shuangfei Cai³, Wei Zhang⁴, Rong Yang⁵

Affiliations

¹ CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Center of Materials Science and Optoelectronics Engineering, CAS center for Excellence in Nanoscience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
² CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Center of Materials Science and Optoelectronics Engineering, CAS center for Excellence in Nanoscience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China; Sino-Danish College, Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing 100049, China.
³ CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Center of Materials Science and Optoelectronics Engineering, CAS center for Excellence in Nanoscience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: [email protected].
⁴ National Key Laboratory of Computational Physics, Institute of Applied Physics and Computational Mathematics, Beijing 100088, China. Electronic address: [email protected].
⁵ CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Center of Materials Science and Optoelectronics Engineering, CAS center for Excellence in Nanoscience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China; Sino-Danish College, Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: [email protected].

PMID: 39536606
DOI: 10.1016/j.colsurfb.2024.114369

Abstract

The unusual accumulation of amyloid-beta 1-42 (Aβ₄₂) is an essential pathological feature of Alzheimer's disease (AD), and development of Aβ₄₂ nanomodulators offers a potentially therapeutic approach to AD. Here, we report facile synthesis of the hollow mesocrystalline Prussian blue nanocages (HMPBs), which serve as versatile Aβ₄₂ modulators. Due to the hollow nanostructures and large specific surface area, they can effectively inhibit Aβ₄₂ aggregation by adsorption. They also exhibit robust near-infrared (NIR) photothermal effect for light-to-heat transition, which promotes the depolymerization of Aβ₄₂ fibers. Besides, they display ROS quenching ability to scavenge hydroxyl radicals (•OH) caused by Aβ₄₂ fibers, alleviate cellular oxidative stress, and improve cell survival. This work provides a new kind of Prussian blue nanomaterial for multimodal Aβ modulation.

Keywords: Alzheimer's disease; Amyloid-beta aggregation; Photothermal; Prussian blue; ROS scavenging.

MeSH terms

Amyloid beta-Peptides* / antagonists & inhibitors
Amyloid beta-Peptides* / chemistry
Amyloid beta-Peptides* / metabolism
Cell Survival* / drug effects
Ferrocyanides* / chemistry
Ferrocyanides* / pharmacology
Free Radical Scavengers* / chemical synthesis
Free Radical Scavengers* / chemistry
Free Radical Scavengers* / pharmacology
Humans
Nanostructures / chemistry
Oxidative Stress / drug effects
Particle Size
Peptide Fragments / chemistry
Peptide Fragments / pharmacology
Reactive Oxygen Species / metabolism
Surface Properties

Substances

Amyloid beta-Peptides
Ferrocyanides
ferric ferrocyanide
Free Radical Scavengers
Peptide Fragments
amyloid beta-protein (1-42)
Reactive Oxygen Species