Urologic Imaging of the Prostate: Cancer and Mimics

Urol Clin North Am. 2025 Feb;52(1):125-138. doi: 10.1016/j.ucl.2024.07.012. Epub 2024 Aug 16.

Abstract

This article provides a comprehensive overview of prostate cancer imaging, including detection of clinically significant cancer and initial staging. The role of multiparametric MRI in detection and local staging is discussed, along with the use of conventional imaging and advanced techniques such as Prostate-Specific Membrane Antigen-Positron Emission Tomography (PSMA-PET) for staging of nodal and distant metastases. The article also highlights the importance of differentiating benign prostatic conditions from prostate cancer on imaging to improve diagnostic accuracy and reduce false-positive interpretations.

Keywords: Multiparametric MRI; PI-RADS 2.1; PSMA-PET; Prostate cancer; Staging.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Multiparametric Magnetic Resonance Imaging
  • Neoplasm Staging
  • Positron-Emission Tomography
  • Prostate / diagnostic imaging
  • Prostate / pathology
  • Prostatic Neoplasms* / diagnostic imaging
  • Prostatic Neoplasms* / pathology