Regular and adequate use of broad-spectrum sunscreen has been proven to offer significant protection against acute Ultraviolet-induced photodamage, photoaging, immunosuppression, and the development of skin tumors. However, concerns regarding the safety and standardized use of sunscreens persist, including potential allergenicity and irritability of certain organic sunscreens, the impact of systemic absorption on the endocrine system, the effect on vitamin D synthesis and absorption, and environmental implications. Special caution is advised when using small molecule organic sunscreens and nanoparticle inorganic sunscreens, especially for infants, pregnant women, and areas with damaged skin.
规律足量使用广谱防晒剂已经被证实对预防紫外线诱导的急性光损伤、皮肤光老化，免疫抑制以及皮肤肿瘤的发生有重要的保护作用。但是，防晒剂的安全性和规范使用依然存在一些值得关注的问题，如某些有机防晒剂的人体致敏性和刺激性，防晒剂系统吸收对内分泌的影响，防晒剂对维生素D的合成和吸收的影响，以及防晒剂对环境的影响。某些小分子的有机防晒剂，纳米级的无机防晒剂存在透皮吸收的可能，婴幼儿、孕妇和损伤皮肤部位使用时需要慎重。.