Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis

Pei-Yao Zhai; Zhi-Xian Chen; Ting Jiang; Jian Feng; Bin Zhang; Xiao Zang; Yan-Lin Zhao; Gang Qin

doi:10.1016/j.drup.2024.101172

Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis

Drug Resist Updat. 2025 Jan:78:101172. doi: 10.1016/j.drup.2024.101172. Epub 2024 Nov 13.

Authors

Pei-Yao Zhai¹, Zhi-Xian Chen², Ting Jiang³, Jian Feng⁴, Bin Zhang⁵, Xiao Zang⁶, Yan-Lin Zhao⁷, Gang Qin⁸

Affiliations

¹ Department of Infectious Diseases, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, JS, China. Electronic address: [email protected].
² Department of Clinical Pharmacy, Nantong Health College of Jiangsu Province, Nantong, JS, China. Electronic address: [email protected].
³ Department of Infectious Diseases, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, JS, China. Electronic address: [email protected].
⁴ National Key Clinical Construction Specialty - Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Nantong, JS, China. Electronic address: [email protected].
⁵ Department of Infectious Diseases, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, JS, China. Electronic address: [email protected].
⁶ Division of Health Policy and Management, University of Minnesota Twin Cities, Minneapolis, MN, USA. Electronic address: [email protected].
⁷ National Center for TB Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address: [email protected].
⁸ Department of Infectious Diseases, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, JS, China; National Key Clinical Construction Specialty - Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Nantong, JS, China. Electronic address: [email protected].

PMID: 39541911
DOI: 10.1016/j.drup.2024.101172

Abstract

This study used a calibrated mathematical model to evaluate age-specific tuberculosis (TB) vaccination strategies, for drug-resistant (DR)-TB management in China. Prioritizing elderly vaccination significantly reduced multidrug-resistant or rifampicin-resistant TB incidence and mortality, while avoiding the need for second-line treatment, offering a promising approach to mitigate DR-TB burden by 2050.

Keywords: Drug resistance; Mathematical model; Tuberculosis; Vaccine.

MeSH terms

Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Antitubercular Agents / pharmacology
Antitubercular Agents / therapeutic use
Child
Child, Preschool
China / epidemiology
Female
Humans
Incidence
Infant
Male
Middle Aged
Models, Theoretical
Mycobacterium tuberculosis / drug effects
Mycobacterium tuberculosis / immunology
Rifampin / pharmacology
Rifampin / therapeutic use
Tuberculosis Vaccines / immunology
Tuberculosis, Multidrug-Resistant* / drug therapy
Tuberculosis, Multidrug-Resistant* / epidemiology
Tuberculosis, Multidrug-Resistant* / prevention & control
Vaccination* / methods
Young Adult

Substances

Tuberculosis Vaccines
Antitubercular Agents
Rifampin