Beta-carbolines suppress vaginal inflammation

Cancan Qi; Ri-Hua Xie; Yan He; Muxuan Chen

doi:10.1016/j.chom.2024.10.005

Beta-carbolines suppress vaginal inflammation

Cell Host Microbe. 2024 Nov 13;32(11):1873-1875. doi: 10.1016/j.chom.2024.10.005.

Authors

Cancan Qi¹, Ri-Hua Xie², Yan He³, Muxuan Chen⁴

Affiliations

¹ Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Guangdong Provincial Clinical Research Center for Laboratory Medicine, Guangzhou, Guangdong, China.
² Women and Children Medical Research Center, Foshan Women and Children Hospital, Foshan, Guangdong, China; School of Nursing, Southern Medical University, Guangzhou, Guangdong, China.
³ Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Guangdong Provincial Clinical Research Center for Laboratory Medicine, Guangzhou, Guangdong, China; State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou, Guangdong, China; Key Laboratory of Mental Health of the Ministry of Education, Guangzhou, Guangdong, China.
⁴ Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Guangdong Provincial Clinical Research Center for Laboratory Medicine, Guangzhou, Guangdong, China. Electronic address: [email protected].

PMID: 39541939
DOI: 10.1016/j.chom.2024.10.005

Abstract

Vaginal lactobacilli are key regulators of host inflammation, yet the mechanisms remain understudied. In this issue of Cell Host & Microbe, Glick et al. identify a family of beta-carbolines as anti-inflammatory effectors produced by vaginal Lactobacillus species, highlighting their potential as therapeutics for vaginal inflammatory disorders.

MeSH terms

Animals
Anti-Inflammatory Agents / pharmacology
Carbolines* / pharmacology
Carbolines* / therapeutic use
Female
Humans
Inflammation / drug therapy
Lactobacillus* / drug effects
Vagina* / immunology
Vagina* / microbiology
Vaginitis / drug therapy
Vaginitis / microbiology

Substances

Carbolines
Anti-Inflammatory Agents