[Of muscle and bone: Diagnostic challenge of an uncommonly located rhabdomyosarcoma]

Ann Pathol. 2025 Jan;45(1):97-102. doi: 10.1016/j.annpat.2024.10.003. Epub 2024 Nov 13.
[Article in French]

Abstract

Rhabdomyosarcomas form a heterogeneous group of malignant soft tissue tumors characterized by immature striated muscle differentiation. Epithelioid and spindle cell rhabdomyosarcoma is a recently described entity, mainly localized intraosseously and predominantly found in young patients. Its late diagnosis and high aggressiveness confer a grim prognosis to this tumor, highlighting the importance of early recognition and appropriate management. We present herein the clinical, histopathological, immunohistochemical, and molecular aspects of this entity through a case of misleading presentation.

Keywords: Epithelioid and spindle cell rhabdomyosarcoma; Intraosseous rhabdomyosarcoma; Pathologie des tissus mous; Pathologie pédiatrique; Pediatric pathology; Rhabdomyosarcome intraosseux; Rhabdomyosarcome à cellules épithélioïdes et fusiformes; Soft tissue pathology; TFCP2.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Biomarkers, Tumor / analysis
  • Bone Neoplasms* / diagnosis
  • Bone Neoplasms* / pathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Muscle Neoplasms* / chemistry
  • Muscle Neoplasms* / diagnosis
  • Muscle Neoplasms* / pathology
  • Rhabdomyosarcoma* / diagnosis
  • Rhabdomyosarcoma* / pathology

Substances

  • Biomarkers, Tumor