Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment

Jun Li; Zhiguo Yuan; Shuyu Shi; Xingtao Chen; Shuangshuang Yu; Xiaoshu Qi; Tong Deng; Yifei Zhou; Dan Tang; Saihong Xu; Jue Zhang; Yingfu Jiao; Weifeng Yu; Liya Wang; Liqun Yang; Po Gao

doi:10.1186/s12951-024-02986-4

Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment

J Nanobiotechnology. 2024 Nov 14;22(1):706. doi: 10.1186/s12951-024-02986-4.

Authors

Jun Li^#^{1

2}, Zhiguo Yuan^#³, Shuyu Shi^#^{1

2}, Xingtao Chen^#⁴, Shuangshuang Yu⁵, Xiaoshu Qi^{1

2}, Tong Deng⁶, Yifei Zhou^{1

2}, Dan Tang^{1

2}, Saihong Xu^{1

2}, Jue Zhang⁶, Yingfu Jiao^{1

2}, Weifeng Yu^{7

8}, Liya Wang^{9

10}, Liqun Yang^{11

12}, Po Gao^{13

14}

Affiliations

¹ Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
² Key Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, China.
³ Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
⁴ Sichuan Provincial Laboratory of Orthopedic Engineering, Department of Orthopedics, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China.
⁵ Department of Dermatology, Chaohu Hospital Affiliated to Anhui Medical University, Chaohu, Anhui, 238000, China.
⁶ Anhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, Wuhu, 241002, China.
⁷ Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. [email protected].
⁸ Key Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, China. [email protected].
⁹ Department of Gynecologic Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China. [email protected].
¹⁰ Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China. [email protected].
¹¹ Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. [email protected].
¹² Key Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, China. [email protected].
¹³ Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. [email protected].
¹⁴ Key Laboratory of Anesthesiology (Shanghai Jiao Tong University), Ministry of Education, Shanghai, China. [email protected].

^# Contributed equally.

Abstract

Treating psoriasis presents a major clinical challenge because of the limitations associated with traditional topical glucocorticoid therapy. This study introduced a drug delivery system utilizing zinc-doped mesoporous silica nanoparticle (Zn-MSN) and microneedle (MN), designed to enhance drug utilization for prolonged anti-inflammatory and anti-itch effects. The MN system facilitated the transdermal delivery of betamethasone dipropionate (BD), allowing its slow release. The BD@Zn-MSN-MN system promoted the polarization of macrophages towards the anti-inflammatory M2 phenotype, achieving superior anti-inflammatory effects compared to the clinically used BD cream. Additionally, this study demonstrated that BD@Zn-MSN-MN could further alleviate itching in psoriasis-afflicted mice by decreasing the excitability of the transient receptor potential vanilloid V1 (TRPV1) ion channel positive neurons and reducing the release of calcitonin gene-related peptide (CGRP) in the dorsal root ganglion (DRG). These findings offer new insights and effective therapeutic options for the future design of transdermal drug delivery for psoriasis.

Keywords: Betamethasone dipropionate; Itch; Mesoporous silica nanoparticle; Microneedle; Psoriasis.

MeSH terms

Administration, Cutaneous*
Animals
Anti-Inflammatory Agents* / chemistry
Anti-Inflammatory Agents* / pharmacology
Betamethasone* / administration & dosage
Betamethasone* / analogs & derivatives
Betamethasone* / chemistry
Betamethasone* / pharmacokinetics
Betamethasone* / pharmacology
Drug Delivery Systems* / methods
Male
Mice
Nanoparticles* / chemistry
Needles
Porosity
Psoriasis* / drug therapy
RAW 264.7 Cells
Silicon Dioxide* / chemistry
Silicon Dioxide* / pharmacology
Zinc* / chemistry
Zinc* / pharmacology

Substances

Betamethasone
Silicon Dioxide
Zinc
betamethasone-17,21-dipropionate
Anti-Inflammatory Agents

Abstract

MeSH terms

Substances

Grants and funding