POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer

Karen M Mann

doi:10.1016/j.tcb.2024.11.002

POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer

Trends Cell Biol. 2024 Nov 14:S0962-8924(24)00233-2. doi: 10.1016/j.tcb.2024.11.002. Online ahead of print.

Author

Karen M Mann¹

Affiliation

¹ Department of Molecular Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA. Electronic address: [email protected].

PMID: 39547880
DOI: 10.1016/j.tcb.2024.11.002

Abstract

Transposable elements (TEs) account for 50% of the human genome and have essential functions as gene promoters. A subset of TEs is expressed in normal cells and differentially expressed in cancers, yet their biological significance is understudied. In a recent article, Tu et al. describe the tumor suppressive function of POGK, an expressed TE with a KRAB domain, and its cooperation with TRIM28 to repress ribosomal gene transcription in triple-negative breast cancer (TNBC).