Unanticipated specificity in effector-triggered immunity

Alejandra Zárate-Potes; Hinrich Schulenburg; Katja Dierking

doi:10.1016/j.it.2024.10.008

Unanticipated specificity in effector-triggered immunity

Trends Immunol. 2024 Dec;45(12):939-942. doi: 10.1016/j.it.2024.10.008. Epub 2024 Nov 15.

Authors

Alejandra Zárate-Potes¹, Hinrich Schulenburg², Katja Dierking³

Affiliations

¹ Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany.
² Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany; Max Planck Institute for Evolutionary Biology, 24306 Ploen, Germany. Electronic address: [email protected].
³ Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany. Electronic address: [email protected].

PMID: 39550315
DOI: 10.1016/j.it.2024.10.008

Abstract

Effector-triggered immunity (ETI) enables hosts to react to pathogens by monitoring few key cellular processes. ETI responses are assumed to be similar toward related pathogen effectors. However, recent evidence from the invertebrate model Caenorhabditis elegans and pore-forming toxins indicates a much more complex and specific ETI than previously anticipated.

MeSH terms

Animals
Caenorhabditis elegans* / immunology
Host-Pathogen Interactions / immunology
Humans
Immunity
Immunity, Innate