A resurfaced sensor NLR confers new recognition specificity to non-MAX effectors

Tongtong Zhu; Xuefeng Wu; Guixin Yuan; Dongli Wang; Vijai Bhadauria; You-Liang Peng; Junfeng Liu; Xin Zhang

doi:10.1111/jipb.13805

A resurfaced sensor NLR confers new recognition specificity to non-MAX effectors

J Integr Plant Biol. 2025 Jan;67(1):11-14. doi: 10.1111/jipb.13805. Epub 2024 Nov 19.

Authors

Tongtong Zhu^{1

2}, Xuefeng Wu^{1

2}, Guixin Yuan^{1

3}, Dongli Wang^{1

2}, Vijai Bhadauria¹, You-Liang Peng^{1

3}, Junfeng Liu^{1

2

4}, Xin Zhang^{1

2}

Affiliations

¹ The State Key Laboratory of Maize Bio-breeding, Joint International Research Laboratory of Crop Molecular Breeding, Ministry of Agriculture Key Laboratory for Crop Pest Monitoring and Green Control, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
² Joint International Research, Laboratory of Crop Molecular Breeding, China Agricultural University, Beijing, 100193, China.
³ Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing, 100193, China.
⁴ Sanya Institute of China Agricultural University, Sanya, 572025, China.

PMID: 39560400
DOI: 10.1111/jipb.13805

Abstract

Replacing the HMA domain of the rice (Oryza sativa) immune receptor RGA5 with that of the rice HMA DOMAIN-CONTAINING PROTEIN 120 (HMA120) creates a designer RGA5^HMA120 that confers resistance to Magnaporthe oryzae isolates expressing the non-MAX effector gene AVR-Pita, thus enabling the generation of new synthetic resistance genes.

Keywords: HMA domain; NLR receptors; non‐MAX effector; resistance; rice.

MeSH terms

Ascomycota
Disease Resistance / genetics
NLR Proteins* / genetics
NLR Proteins* / metabolism
Oryza* / genetics
Oryza* / metabolism
Oryza* / microbiology
Plant Diseases / genetics
Plant Diseases / immunology
Plant Diseases / microbiology
Plant Proteins* / genetics
Plant Proteins* / metabolism

A resurfaced sensor NLR confers new recognition specificity to non-MAX effectors

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