Drug monitoring was conducted for rifapentine among people with HIV receiving dolutegravir containing antiretroviral therapy and latent tuberculosis treatment

Jeng-Hung Chen; Yi-Chun Lin; Cheng-Pin Chen; Shu-Hsing Cheng; Hui-Chun Hu; Hsiu-Wen Yeh; Hui-Ting Shieh; Chien-Yu Cheng

doi:10.1016/j.jmii.2024.11.002

Drug monitoring was conducted for rifapentine among people with HIV receiving dolutegravir containing antiretroviral therapy and latent tuberculosis treatment

J Microbiol Immunol Infect. 2024 Nov 14:S1684-1182(24)00208-1. doi: 10.1016/j.jmii.2024.11.002. Online ahead of print.

Authors

Jeng-Hung Chen¹, Yi-Chun Lin², Cheng-Pin Chen³, Shu-Hsing Cheng⁴, Hui-Chun Hu⁵, Hsiu-Wen Yeh⁶, Hui-Ting Shieh⁷, Chien-Yu Cheng⁸

Affiliations

¹ Department of Pharmacology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City 330, Taiwan. Electronic address: [email protected].
² Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City, 330, Taiwan. Electronic address: [email protected].
³ Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City, 330, Taiwan; School of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei City, 112, Taiwan. Electronic address: [email protected].
⁴ Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City, 330, Taiwan; School of Public Health, Taipei Medical University, Taipei City, 110, Taiwan. Electronic address: [email protected].
⁵ Department of Nursing, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City, 330, Taiwan. Electronic address: [email protected].
⁶ Department of Nursing, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City, 330, Taiwan. Electronic address: [email protected].
⁷ Comprehensive AIDS Care Center, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, 330, Taiwan. Electronic address: [email protected].
⁸ Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City, 330, Taiwan; Institute of Public Health, School of Medicine, National Yang-Ming Chiao Tung University, Taipei City, 112, Taiwan. Electronic address: [email protected].

PMID: 39562192
DOI: 10.1016/j.jmii.2024.11.002

Abstract

The proportion of trough plasma concentration of dolutegravir (DTG) above protein adjusted 90 % inhibition concentration (IC90) (0.064 mg/L) was 98.1 % across all visits during the twelve doses of once-weekly rifapentine and isoniazid (3HP) in people with HIV (PWH). Furthermore, the participants maintained a high rate of HIV viral suppression (98 %) within 6 months after completing 3HP.

Keywords: 3HP; Dolutegravir; Latent tuberculosis infection; Rifapentine.