Ferroptosis-disease perils and therapeutic promise

Science. 2024 Nov 22;386(6724):848-849. doi: 10.1126/science.adn7030. Epub 2024 Nov 21.

Authors

Ashley R Brown¹, Tal Hirschhorn¹, Brent R Stockwell^{1

2

3

4}

Affiliations

¹ Department of Biological Sciences, Columbia University, New York, NY, USA.
² Department of Chemistry, Columbia University, New York, NY, USA.
³ Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
⁴ Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.

PMID: 39571009
DOI: 10.1126/science.adn7030

Abstract

Mechanisms of iron-dependent cell death reveal potential new targets for disease treatment.

MeSH terms

Animals
Ferroptosis* / drug effects
Hemochromatosis* / metabolism
Hemochromatosis* / therapy
Humans
Iron* / metabolism
Neoplasms* / metabolism
Neoplasms* / therapy
Neurodegenerative Diseases* / metabolism
Neurodegenerative Diseases* / therapy

Substances

Iron