Effect of XBB.1.5-adapted booster vaccination on the imprinting of SARS-CoV-2 immunity

Jernej Pušnik; Werner O Monzon-Posadas; Emmanuil Osypchuk; Aleksandra Elzbieta Dubiel; Maximilian Baum; Paulina Fehring; Antonia Büning; Tobias Klant; Hendrik Streeck

doi:10.1038/s41541-024-01023-7

Effect of XBB.1.5-adapted booster vaccination on the imprinting of SARS-CoV-2 immunity

NPJ Vaccines. 2024 Nov 21;9(1):231. doi: 10.1038/s41541-024-01023-7.

Authors

Jernej Pušnik^{1

2}, Werner O Monzon-Posadas^{3

4

5}, Emmanuil Osypchuk^{3

4}, Aleksandra Elzbieta Dubiel^{3

4}, Maximilian Baum^{3

4}, Paulina Fehring^{3

4}, Antonia Büning^{3

4}, Tobias Klant³, Hendrik Streeck^{3

4}

Affiliations

¹ Institute of Virology, University Hospital Bonn, Bonn, 53127, Germany. [email protected].
² German Center for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, 53127, Germany. [email protected].
³ Institute of Virology, University Hospital Bonn, Bonn, 53127, Germany.
⁴ German Center for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, 53127, Germany.
⁵ Occupational Medicine Department, University Hospital Bonn, Bonn, 53127, Germany.

Abstract

In the present study, Pušnik et al. investigated whether the XBB.1.5-adapted booster can overcome the persistent imprinting of SARS-CoV-2 immunity by wild-type based vaccines. The findings demonstrate increased plasma neutralization against the homologous variant following the booster vaccination. Formation of de novo humoral response against the mutated epitopes of XBB.1.5 variant's surface proteins was observed in 3/20 individuals. The booster vaccination had no significant effect on T-cell response.