One-dimensional sub-wavelength gratings are versatile photonic platforms supporting diverse resonances, including symmetry-protected bound states in the continuum. However, practical access to these bound modes relies on their quasi-bound form, which necessitates the introduction of perturbations in either geometry or material properties. Despite having a large, finite quality factor, quasi-bound modes retain their characteristically strong field confinement. Gaining control over field localization and leakage of quasi-bound modes requires an investigation not limited to studying the degree of asymmetry and the incoming polarization. Here, we demonstrate that by carefully combining specific types of asymmetries and refractive index contrast between the grating and its surrounding environment, one can tailor field localization and Q-factor almost at will. Our findings reveal a strategic roadmap for optimizing quasi-bound mode implementation, dramatically improving their use in applications such as optical communication, sensing, and nonlinear optical processes.