Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype

Affiliations

• ¹ Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• ² Pulmonary, Critical Care and Sleep Medicine, Medicine, University of Washington, Seattle, WA, USA.
• ³ Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
• ⁴ Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• ⁵ Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
• ⁶ Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
• ⁷ Sleep Disorders Center, VA Boston Healthcare System.
• ⁸ The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
• ⁹ Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.
• ¹⁰ Framingham Heart Study, Framingham, Massachusetts, Boston, MA, USA.
• ¹¹ Department of Epidemiology, School of Public Health, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
• ¹² Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
• ¹³ Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
• ¹⁴ Westat, Rockville, Maryland, USA.
• ¹⁵ Adelaide Institute for Sleep Health / Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia.
• ¹⁶ Sleep Health Service, Respiratory and Sleep Service, Southern Adelaide Local Health Network, Bedford Park, South Australia, Australia.
• ¹⁷ Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
• ¹⁸ Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
• ¹⁹ Australian Institute for Machine Learning, University of Adelaide, Adelaide, SA, Australia.
• ²⁰ School of Public Health, University of Adelaide, Adelaide, SA, Australia.
• ²¹ Center for Sleep and Cardiovascular Outcomes Research, University of Pittsburgh, Pittsburgh, PA, USA.
• ²² Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
• ²³ Department of Epidemiology, University of Washington, Seattle, WA, USA.
• ²⁴ Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
• ²⁵ Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
• ²⁶ Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
• ²⁷ Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
• ²⁸ Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
• ²⁹ Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
• ³⁰ Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
• ³¹ Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
• ³² California Pacific Medical Center Research Institute, San Francisco and Department of Epidemiology and Biostatistics, University of California, San Francisco, USA.
• ³³ Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
• ³⁴ CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA.