Research progress of CD80 in the development of immunotherapy drugs

Front Immunol. 2024 Nov 7:15:1496992. doi: 10.3389/fimmu.2024.1496992. eCollection 2024.

Abstract

CD80 is a molecule that plays an important role in the immune system, especially during T-cell activation, and its ligands are mainly CD28, PD-L1, and CTLA-4. CD80 is expressed on the surface of tumor cells, and it can be used as a molecular target in the process of T-cell anti-tumor immune response. In autoimmune diseases, CD80 can also regulate autoimmune diseases by modulating immunity. This review mainly focus on the role of CD80 in the immune system, as well as the research progress on the application of CD80-related immunopharmaceuticals in the treatment of tumors and autoimmune diseases.

Keywords: CD80; T cells; autoimmune diseases; immunotherapy drugs; tumor.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases* / drug therapy
  • Autoimmune Diseases* / immunology
  • Autoimmune Diseases* / therapy
  • B7-1 Antigen* / immunology
  • B7-1 Antigen* / metabolism
  • Drug Development
  • Humans
  • Immunotherapy* / methods
  • Neoplasms* / drug therapy
  • Neoplasms* / immunology
  • Neoplasms* / therapy

Substances

  • B7-1 Antigen
  • CD80 protein, human

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by The First batch of key Disciplines On Public Health in Chongqing. Application of single cell biomolecular analysis in the pathogenesis of lung cancer (cstc2022yejh-bgzxm0051).