Modular Synthesis of Geminal Iododiboron Compounds via Alkylation of Chlorodiborylmethane

Org Lett. 2024 Dec 6;26(48):10285-10290. doi: 10.1021/acs.orglett.4c03804. Epub 2024 Nov 22.

Abstract

α-Halogenated geminal bis(boronates) are emerging as multifunctional building blocks for organic synthesis. Currently, their synthetic utilization is still restricted due to a lack of efficient preparation methods. Herein, we report a direct, modular synthesis of gem-iododiborylalkanes using alkyl halides and a lithiated chlorodiborylmethane reagent. Compared with previously reported methods, this protocol features modular assembly, high efficiency, and good tolerance to various functional groups.