Exploring the structure-activity relationship of Safflower polysaccharides: From the structural characteristics to biological function and therapeutic applications

Ethnopharmacological relevance: Safflower, the florets of Carthamus tinctorius L., is a widely used traditional Chinese medicine for promoting circulation and improving dysmenorrhea. Polysaccharides is one of the principal water-soluble components in Safflower, which recently endowed with a variety of biological activities, thus making them have important research significance in the field of ethnopharmacology.

Aim of the study: This review summarized the latest research progress on the preparation technology, structural characteristics, and pharmacological effects of Safflower polysaccharides. Moreover, by comparing the structural characteristic of Safflower polysaccharides, the potential structure-activity relationship of Safflower polysaccharides was also discussed.

Materials and methods: This article used keywords including Safflower polysaccharide, Carthamus tinctorius L polysaccharide, Safflower polysaccharide extraction and separation, Safflower polysaccharide structure, and Safflower polysaccharide anti-tumor effects to search for all relevant literature in PubMed, Web of Science, Google Scholar, ScienceDirect, CNKI and other databases from the establishment of the database to July 2024.

Results: Summarizing current research findings, seventeen homogeneous Safflower polysaccharides have been obtained. Their structural characteristics, including molecular weights, monosaccharide composition, sugar residue types, glycosidic bond configuration, and the linkage sequence, were initially researched. In terms of pharmacological activity, Safflower polysaccharides exhibit a wide range of biological activities, including immune regulation, anti-tumor effects, and antioxidant properties. Furthermore, the structural characteristics of Safflower polysaccharides significantly influence its biological activities, encompassing factors such as molecular weight, monosaccharide composition, and degree of branching.

Conclusion: Safflower polysaccharides have seen significant advancements in recent years regarding preparation methods, structural characterization, and pharmacological studies. These achievements would provide a theoretical basis for the application of Safflower polysaccharide in the field of ethnopharmacology. While Safflower polysaccharides exhibit diverse biological activities and significant potential for development and utilization, further in-depth research is needed to enhance our understanding of their mechanisms of action and optimize their clinical applications.