Background: Among patients with functional mitral regurgitation (FMR), responders to transcatheter mitral edge-to-edge repair (TEER) remain unclear. We investigated whether the slope of the preload recruitable stroke work relationship (Mw; calculated as stroke work / [EDV - k × EDV + {1 - k} × LV wall], where EDV is end-diastolic volume, k is a constant, and LV wall is the volume of the left ventricular wall) could predict rehospitalization in FMR patients after TEER.
Methods and results: Mwwas calculated for 24 FMR patients using echocardiography. The median left ventricular ejection fraction was 27% and the median Mwwas 32. Over a 498-day median follow-up period, 38% of patients were rehospitalized for heart failure, and only Mwhad a high area under the curve in time-dependent receiver operating characteristic analysis.
Conclusions: Mwis an effective predictor for rehospitalization in FMR patients after TEER.
Keywords: Functional mitral regurgitation; Slope of the preload recruitable stroke work relationship (Mw); Transcatheter mitral edge-to-edge repair (TEER).