The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review

Muhamad Alojid Anis Amiera; Tuan Noorkorina Tuan Kub; Azian Harun; Rohimah Mohamud; Nur Rina Alissa Razian; Yasmin Khairani Muhammad Ismadi; Wan Alif Syazwani Wan Alias; Mohammed Hussain Abdulrazak; Ernawati Teni

doi:10.7717/peerj.18513

The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review

PeerJ. 2024 Nov 20:12:e18513. doi: 10.7717/peerj.18513. eCollection 2024.

Authors

Muhamad Alojid Anis Amiera¹, Tuan Noorkorina Tuan Kub¹, Azian Harun¹, Rohimah Mohamud², Nur Rina Alissa Razian¹, Yasmin Khairani Muhammad Ismadi¹, Wan Alif Syazwani Wan Alias¹, Mohammed Hussain Abdulrazak¹, Ernawati Teni³

Affiliations

¹ Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
² Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
³ National Research and Innovation Agency (BRIN), Research Centre for Pharmaceutical Ingredients and Traditional Medicines, Yogjakarta, Indonesia.

Abstract

Objective: To critically analyse literature on the anticancer properties of andrographolide in in vitro studies on gastric cancer cells.

Method: This study systematically reviewed articles from 2013 to 2024 across five prominent databases; PubMed, Google Scholar, Web of Science, Scopus, and Science Direct, EMBASE, Cochrane library and DOAJ. The study eligibility criteria include original studies assessing using gastric cancer cell lines and articles utilizing extracted andrographolide from Andrographis paniculata or standard andrographolide source treatment. The following exclusion criteria were articles written in a different language, review articles, book chapters, conference articles, scientific reports. Duplicated articles were removed using Mendeley software.

Result: Out of 93 articles, six were relevant, primarily focusing on in vitro analyses with gastric adenocarcinoma cell lines.

Conclusion: These studies indicate that andrographolide can hinder the cell cycle, suppress cell proliferation, alleviate oxidative stress, and induce apoptosis by prompting gastric cancer cells to undergo self-destruction, which is a crucial mechanism for controlling and eliminating cancerous growths.

Keywords: Andrographis paniculata; Andrographolide; Anticancer; Gastric cancer cell lines; In vitro.

Publication types

Systematic Review

MeSH terms

Andrographis / chemistry
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use
Antineoplastic Agents, Phytogenic / pharmacology
Antineoplastic Agents, Phytogenic / therapeutic use
Apoptosis* / drug effects
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation* / drug effects
Diterpenes* / pharmacology
Diterpenes* / therapeutic use
Humans
Oxidative Stress / drug effects
Stomach Neoplasms* / drug therapy
Stomach Neoplasms* / pathology

Substances

Diterpenes
andrographolide
Antineoplastic Agents
Antineoplastic Agents, Phytogenic

Grants and funding

This work was supported by the Malaysian Ministry of Higher Education for the financial support via a Fundamental Research Grant Scheme (FRGS/1/2022/SKK12/USM/03/5) for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.