Odor identification and progression to dementia: The role of odor characteristics and set size

Introduction: We evaluated short versions of a 16-item odor identification (OID) test, with regard to their ability to identify individuals at high dementia risk.

Methods: Participants from the population-based SNAC-K study (n = 2418) were followed across 12 years. We formed 13 abbreviated clusters based on the identifiability and perceptual characteristics of the Sniffin' Sticks Test (SST) items, and pre-existing test versions. Dementia hazard was estimated with Cox regressions.

Results: Lower OID scores were associated with an increased dementia hazard across all odor clusters. Lower performance in the high identifiability cluster showed the strongest association with dementia (hazard ratio = 1.39, 95% confidence interval [1.28-1.51]). Moreover, the high-intensity odor cluster showed a stronger association with dementia than the low-intensity cluster (P = 0.02).

Discussion: The findings suggest that the SST items differ with regard to their association with dementia and support using a reduced set size for clinical practice.

Highlights: Odor identification (OID) items differ in their association with future dementia.Reduced OID set sizes render hazard ratios comparable to larger set sizes.Identifiability and perceptual characteristics of odors should be considered when designing dementia screening instruments.