A Semiparametric Two-Sample Density Ratio Model With a Change Point

Biom J. 2024 Dec;66(8):e202300214. doi: 10.1002/bimj.202300214.

Abstract

The logistic regression model for a binary outcome with a continuous covariate can be expressed equivalently as a two-sample density ratio model for the covariate. Utilizing this equivalence, we study a change-point logistic regression model within the corresponding density ratio modeling framework. We investigate estimation and inference methods for the density ratio model and develop maximal score-type tests to detect the presence of a change point. In contrast to existing work, the density ratio modeling framework facilitates the development of a natural Kolmogorov-Smirnov type test to assess the validity of the logistic model assumptions. A simulation study is conducted to evaluate the finite-sample performance of the proposed tests and estimation methods. We illustrate the proposed approach using a mother-to-child HIV-1 transmission data set and an oral cancer data set.

Keywords: biased sampling; empirical likelihood; goodness‐of‐fit; logistic regression model; score test.

MeSH terms

  • Biometry* / methods
  • Female
  • HIV Infections*
  • HIV-1
  • Humans
  • Infectious Disease Transmission, Vertical / statistics & numerical data
  • Logistic Models
  • Models, Statistical*
  • Mouth Neoplasms / pathology