Exploring end-of-life decision-making in China for disorders of consciousness

Ann Med. 2024 Dec;56(1):2423794. doi: 10.1080/07853890.2024.2423794. Epub 2024 Nov 25.

Abstract

Objectives: We aim to investigate the ethical attitudes of the Chinese population toward withdrawal of life-sustaining treatment (WLST) in disorders of consciousness (DoC) patients.

Methods: A self-administered questionnaire concerning WLST was distributed to Chinese medical professionals and non-medical participants between February and July 2022. Statistical analysis included chi-square tests and logistic regressions.

Results: A total of 1223 Chinese participants responded to the questionnaire (39% of whom were medical professionals). Less than one third of participants reported positive attitudes towards withdrawing artificial nutrition and hydration (ANH), antibiotics, and do-not-resuscitation (DNR) orders in patients with unresponsive wakefulness syndrome (UWS) (30%, 24%, 24%) and minimally conscious state (MCS) (23%, 19%, 15%). More respondents agreed with WLST in UWS compared to MCS (p < 0.05). Positive attitudes toward DNR orders were associated with participants' older age, religion, monthly income > 5000 RMB and medical profession (p < 0.05). Most participants deemed patient's will (78%), families' wishes (67%), and financial burden (63%) to be crucial factors when considering WLST.

Conclusions: Chinese respondents exhibit a relatively low propensity to accept WLST in DoC. Ethical attitudes toward WLST resulted to be affected by individual characteristics of responders. These results call for developing better regulations for identifying qualified surrogate decision-makers and reducing legal ambiguities.

Keywords: Withdrawal of life-sustaining treatment; decision-making; disorders of consciousness; do-not-resuscitation orders; ethics.

MeSH terms

  • Adult
  • Aged
  • Attitude of Health Personnel
  • China
  • Consciousness Disorders* / therapy
  • Decision Making* / ethics
  • Female
  • Humans
  • Male
  • Middle Aged
  • Resuscitation Orders / ethics
  • Surveys and Questionnaires
  • Terminal Care / ethics
  • Terminal Care / psychology
  • Withholding Treatment* / ethics
  • Young Adult

Grants and funding

This work was supported by the National Natural Science Foundation of China (81920108023), and the National Key Research and Development Program of China (Nos. 2022YFC3601200 and 2022YFE0141300). Interdisciplinary Research Project of Hangzhou Normal University (No. 2024JCXK07). BC is doctoral candidate at the GIGA Doctoral School for Health Science (University of Liege) and FNRS-ASP.; OG is a research associate and SL is research director at F.R.S.-FNRS.