Placenta Accreta Spectrum: Risk Factors for Unplanned Immediate Hysterectomy in Planned Uterine Preservation Surgery

Lior Friedrich; Nitzan Mor; Alina Weissmann-Brenner; Eran Kassif; Shakad Noah Friedrich; Tal Weissbach; Elias Castel; Gabriel Levin; Raanan Meyer

doi:10.1055/a-2486-9070

Placenta Accreta Spectrum: Risk Factors for Unplanned Immediate Hysterectomy in Planned Uterine Preservation Surgery

Am J Perinatol. 2024 Dec 24. doi: 10.1055/a-2486-9070. Online ahead of print.

Authors

Lior Friedrich^{1

2}, Nitzan Mor¹, Alina Weissmann-Brenner^{1

2}, Eran Kassif^{1

2}, Shakad Noah Friedrich³, Tal Weissbach^{1

2}, Elias Castel^{1

2}, Gabriel Levin^{4

5}, Raanan Meyer^{1

2

6}

Affiliations

¹ School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
² Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat-Gan, Israel.
³ Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
⁴ Department of Gynecologic Oncology, Hadassah Medical Center, Jerusalem, Israel.
⁵ Faculty of Medicine, Hebrew University, Jerusalem, Israel.
⁶ Dr. Pinchas Bornstein Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel.

PMID: 39592105
DOI: 10.1055/a-2486-9070

Abstract

Objective: Placenta accreta spectrum (PAS) is a term used to describe trophoblast invasion into the uterine wall. The condition can be FATAL: at labor due to a lack of spontaneous separation of the placenta from the uterine wall, leading to severe hemorrhage. In this study, we aim to evaluate preoperative risk factors for unplanned immediate hysterectomy in PAS uterine-preserving surgeries.

Study design: Preoperative parameters of women who underwent successful uterine-preserving surgery were retrospectively compared with those who underwent an unplanned immediate hysterectomy during these surgeries. A multivariable regression analysis was conducted to identify independent factors associated with unplanned immediate hysterectomy.

Results: Overall, 238 were included in the study's cohort. A total of 86.2% underwent successful uterine-preserving surgery, and 13.8% underwent an unplanned immediate hysterectomy. The number of previous cesarean deliveries (CDs) and the proportion of women with grade 3 preoperative PAS was significantly lower among the successful uterine-preserving group. The proportion of preoperative ultrasound lacunae detection, the number of lacunae observed, loss of clear zone detection, the length of clear zone loss, the proportion of retroplacental hypervascularity, bridging vessels detection, and bladder involvement were significantly lower in the successful uterine-preserving group. In a multivariable regression analysis, the presence of lacunae and loss of clear zone were independently associated with unplanned cesarean hysterectomy (adjusted odds ratio [aOR] = 3.18 [95% confidence interval (CI): 1.11-11.6], p = 0.047, and aOR = 3.67 [95% CI: 1.3-13.2], p = 0.025, respectively].

Conclusion: Preoperative assessment of the applicability of a uterine-preserving surgery may be performed using the ultrasound parameters reported in this study.

Key points: · Applicability of a uterine-preserving surgery may be performed using sonographic parameters.. · Sonographic presence of lacunae is associated with an unplanned hysterectomy.. · Sonographic loss of clear zone is associated with an unplanned hysterectomy..