Breaking down IgA: Tomasiella immunophila enlightens microbiome-immune interactions

Duncan B Sutherland; Lucia M Kato; Sidonia Fagarasan

doi:10.1016/j.it.2024.11.003

Breaking down IgA: Tomasiella immunophila enlightens microbiome-immune interactions

Trends Immunol. 2024 Dec;45(12):928-930. doi: 10.1016/j.it.2024.11.003. Epub 2024 Nov 27.

Authors

Duncan B Sutherland¹, Lucia M Kato², Sidonia Fagarasan³

Affiliations

¹ Ludwig Group, Environmental Engineering Institute, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.
² Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan. Electronic address: [email protected].
³ Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan; Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

PMID: 39603890
DOI: 10.1016/j.it.2024.11.003

Abstract

The recent discovery by Lu and colleagues of Tomasiella immunophila, a bacterium that degrades IgA, offers insights into microbial influences on mucosal immunity and evolutionary immune trade-offs. By modulating IgA titers, T. immunophila influences the dynamic interactions and balance between the host and pathogen. This has implications for immune health, microbiome research, and therapeutics.

MeSH terms

Animals
Gastrointestinal Microbiome / immunology
Host-Pathogen Interactions / immunology
Humans
Immunity, Mucosal
Immunoglobulin A* / immunology
Immunoglobulin A* / metabolism
Microbiota* / immunology

Substances

Immunoglobulin A