Multisystem inflammatory syndrome in children presenting as acute severe necrotizing pancreatitis: A case report

Hanna Distel; Kelley Hutchins; Prashant J Purohit; Rodolfo E Bégué

doi:10.1002/jpr3.12113

Multisystem inflammatory syndrome in children presenting as acute severe necrotizing pancreatitis: A case report

JPGN Rep. 2024 Jul 20;5(4):567-571. doi: 10.1002/jpr3.12113. eCollection 2024 Nov.

Authors

Hanna Distel¹, Kelley Hutchins², Prashant J Purohit³, Rodolfo E Bégué⁴

Affiliations

¹ Department of Pediatrics, John A Burns School of Medicine University of Hawai'i Honolulu Hawaii USA.
² Division of Hematology Oncology University of Hawai'I Honolulu Hawaii USA.
³ Division of Critical Care Medicine University of Hawai'I Honolulu Hawaii USA.
⁴ Division of Infectious Diseases University of Hawai'I Honolulu Hawaii USA.

Abstract

We report a case of moderately severe acute pancreatitis, hyperglycemia, acidosis, splenic, superior mesenteric, and portal vein thrombosis in relation to multisystem inflammatory syndrome in children (MIS-C). The patient responded well to intravenous immune globulin, corticosteroids, antibiotics, systemic anticoagulation, and drainage of peripancreatic fluid. The case highlights the polymorphic presentation of MIS-C and advises high level of suspicion for unusual, severe cases unresponsive to routine care.

Keywords: MIS‐C; SARS‐CoV‐2; Spike protein; thrombosis.

© 2024 The Author(s). JPGN Reports Published by Wiley Periodicals LLC. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.