Two novel butyrolactone lignan dimers from leaves of Castanopsis chinensis and their anti-inflammatory activities

J Nat Med. 2024 Nov 29. doi: 10.1007/s11418-024-01864-5. Online ahead of print.

Abstract

Castanopsis genus (Fagaceae) were rich in plant polyphenols and often used as medicinal plants. In this study, two new lignan dimer compounds with anti-inflammatory activity and four known compounds were isolated and identified from 80% methanolic extract of Castanopsis chinensis leaves. The structure determination supported by computational chemistry and extensive spectroscopic analysis. Two new lignan dimer compounds significantly inhibited LPS-induced NO production in RAW 264.7 cells at 10 µM without cytotoxicity.

Keywords: Castanopsis chinensis; Caffeoylquinic acid; ECD; Lignan dimers.