Fibrillary Glomerulonephritis Associated With Hashimoto's Thyroiditis

Cureus. 2024 Oct 30;16(10):e72736. doi: 10.7759/cureus.72736. eCollection 2024 Oct.

Abstract

Fibrillary glomerulonephritis is a rare glomerular disease with some correlations between this condition alongside viral infections, malignancy, and autoimmune pathologies. However, the question regarding the pathogenesis is whether patients who develop fibrillary glomerulonephritis do so irrespective of these other pathologies or whether such pathologies induce fibrillary glomerulonephritis through an unknown mechanism. As such, attempts have been made to create associations with this disease to demonstrate further understanding. Here, we would like to present a very rare case of a patient with Hashimoto's thyroiditis associated with fibrillary glomerulonephritis and how such a diagnosis was made. Although autoimmune associations have been made alongside fibrillary glomerulonephritis, this case demonstrates one of the first cases of a patient with fibrillary glomerulonephritis and Hashimoto's thyroiditis. A discussion regarding the treatment and management of our patient, as well as the pathogenesis of this disease, will also be included.

Keywords: associated; autoimmune disease; cyclophosphamide; dnajb9; fibrillary glomerulonephritis; hashimoto’s thyroiditis; immunosuppressive medications; nonamyloid fibrillary glomerular disease; p-anca; rituximab.

Publication types

  • Case Reports