Abstract
High-grade serous ovarian carcinoma is marked by chromosomal instability, which can serve to promote disease progression and allow cancer to evade therapeutic insults. The report highlights the role of claudin-4 in regulating genomic instability and proposes a novel therapeutic approach to exploit claudin-4-mediated regulation.
©2024 The Authors; Published by the American Association for Cancer Research.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Cycle
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Cell Line, Tumor
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Cell Nucleus / metabolism
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Cell Survival
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Claudin-4* / genetics
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Claudin-4* / metabolism
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Female
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Gene Expression Regulation, Neoplastic
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Genomic Instability*
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Humans
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Ovarian Neoplasms* / genetics
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Ovarian Neoplasms* / metabolism
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Ovarian Neoplasms* / pathology
Substances
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Claudin-4
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CLDN4 protein, human