This article is a call to action for transformative health equity initiatives empowering communities to address systemic health inequities through expanded implementation and enhanced evaluation of health equity zone models. These models prioritize community capacity building and power sharing for upstream, transformative change, urging increased investment in transformative public health practice. Lessons from Rhode Island and Chicago, Illinois, highlight strategies for preventing health inequities and reducing downstream needs among vulnerable populations, underscoring the need for developing innovative evaluation practices measuring transformative change. (Am J Public Health. 2025;115(1):47-51. https://doi.org/10.2105/AJPH.2024.307872).