Mitochondrial respiratory supercomplexes gear up for heat generation in brown adipose tissue

Andreas Carlström; Martin Ott

doi:10.1016/j.cmet.2024.10.022

Mitochondrial respiratory supercomplexes gear up for heat generation in brown adipose tissue

Cell Metab. 2024 Dec 3;36(12):2491-2492. doi: 10.1016/j.cmet.2024.10.022.

Authors

Andreas Carlström¹, Martin Ott²

Affiliations

¹ Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
² Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, 405 30 Gothenburg, Sweden. Electronic address: [email protected].

PMID: 39631368
DOI: 10.1016/j.cmet.2024.10.022

Abstract

Mitochondrial energy conversion supplies cellular energy but can also provide heat in brown adipose tissue (BAT). In a recent study, Shin and Latorre-Muro et al.¹ show that respiratory supercomplexes in BAT are remodeled during cold to provide a tighter coupling, revealing a novel, physiologically important role for these supramolecular assemblies.

MeSH terms

Adipose Tissue, Brown* / metabolism
Animals
Energy Metabolism
Humans
Mitochondria* / metabolism
Thermogenesis*