Case Report of an Urgent Determination of Malignant Hyperthermia Status of a 24-Week Pregnant Patient Requiring Intrauterine Fetal Surgery

A A Pract. 2024 Dec 5;18(12):e01868. doi: 10.1213/XAA.0000000000001868. eCollection 2024 Dec 1.

Abstract

Malignant hyperthermia (MH) is a potentially fatal disorder triggered by volatile anesthetics or succinylcholine, inducing a hypermetabolic crisis in susceptible patients. The caffeine-halothane contracture test (CHCT) remains a gold standard for MH detection. The authors describe a pregnant patient with a history of exertional rhabdomyolysis, who required urgent MH screening for administration of MH-triggering anesthetics. This anesthetic plan allowed for an in utero myelomeningocele repair for a 24-week-old fetus. A multi-institutional team coordinated the urgent CHCT and repair with a favorable outcome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anesthetics, Inhalation / administration & dosage
  • Caffeine / administration & dosage
  • Female
  • Halothane
  • Humans
  • Malignant Hyperthermia* / diagnosis
  • Meningomyelocele / surgery
  • Pregnancy
  • Rhabdomyolysis

Substances

  • Caffeine
  • Halothane
  • Anesthetics, Inhalation