Enhanced Surface Plasmon Resonance Sensing via Kramers-Kronig Phase Extraction

Anal Chem. 2024 Dec 17;96(50):20033-20038. doi: 10.1021/acs.analchem.4c04754. Epub 2024 Dec 5.

Abstract

This study introduces a novel approach to enhance surface plasmon resonance (SPR) sensing using Kramers-Kronig (K-K) relations for phase extraction from reflection spectra. By applying the K-K relations, a phase shift sensitivity of 3400°/RIU is achieved improving SPR detection limits to 9 × 10-6 RIU, which is four times more sensitive than conventional methods for determining SPR peak shifts. This advancement enables more precise detection of refractive index changes in aqueous solutions, making it valuable for biosensing and environmental monitoring with spectrometers.