Intricate ribosome composition and translational reprogramming in epithelial-mesenchymal transition

Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2408114121. doi: 10.1073/pnas.2408114121. Epub 2024 Dec 5.

Abstract

Epithelial-mesenchymal transition (EMT) involves profound changes in cell morphology, driven by transcriptional and epigenetic reprogramming. However, evidence suggests that translation and ribosome composition also play key roles in establishing pathophysiological phenotypes. Using genome-wide analyses, we reported significant rearrangement of the translational landscape and machinery during EMT. Specifically, a cell line overexpressing the EMT transcription factor ZEB1 displayed alterations in translational reprogramming and fidelity. Furthermore, using riboproteomics, we unveiled an increased level of the ribosomal protein RPL36A in mesenchymal ribosomes, indicating precise tuning of ribosome composition. Remarkably, RPL36A overexpression alone was sufficient to trigger the acquisition of mesenchymal features, including a switch in the molecular pattern, cell morphology, and behavior, demonstrating its pivotal role in EMT. These findings underline the importance of translational reprogramming and fine-tuning of ribosome composition in EMT.

Keywords: EMT; RPL36A; ZEB1; ribosome; translation.

MeSH terms

  • Cellular Reprogramming
  • Epithelial-Mesenchymal Transition* / genetics
  • Humans
  • Protein Biosynthesis*
  • Ribosomal Proteins* / genetics
  • Ribosomal Proteins* / metabolism
  • Ribosomes* / metabolism
  • Zinc Finger E-box-Binding Homeobox 1* / genetics
  • Zinc Finger E-box-Binding Homeobox 1* / metabolism

Substances

  • Ribosomal Proteins
  • Zinc Finger E-box-Binding Homeobox 1
  • ZEB1 protein, human