Genetic risk factors for late-onset Alzheimer's disease drive senescence in female tauopathy mice

Tiffany Hensley-McBain; Miranda E Orr

doi:10.1016/j.neuron.2024.10.025

Genetic risk factors for late-onset Alzheimer's disease drive senescence in female tauopathy mice

Neuron. 2024 Dec 4;112(23):3811-3813. doi: 10.1016/j.neuron.2024.10.025.

Authors

Tiffany Hensley-McBain¹, Miranda E Orr²

Affiliations

¹ McLaughlin Research Institute, Great Falls, MT 59405, USA; Touro College of Osteopathic Medicine, Great Falls, MT 59405, USA.
² Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; St. Louis VA Medical Center, St. Louis, MO, USA. Electronic address: [email protected].

PMID: 39637835
DOI: 10.1016/j.neuron.2024.10.025

Abstract

Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular senescence, a hallmark of aging, in a tau- and sex-dependent manner. Mechanistic insights into interactions among genetic risk, biological aging, and sex differences in LOAD are presented.

MeSH terms

Aging / genetics
Alzheimer Disease* / genetics
Alzheimer Disease* / pathology
Animals
Cellular Senescence / genetics
Disease Models, Animal
Female
Humans
Male
Mice
Mice, Transgenic
Risk Factors
Sex Characteristics
Tauopathies* / genetics
Tauopathies* / pathology
tau Proteins / genetics
tau Proteins / metabolism

Substances

tau Proteins