Metabolic dysfunction-associated steatotic liver disease and risk of four intrahepatic and extrahepatic diseases

Yiyuan Xiao; Sihua Xu; Wenyan Hu; Jiapeng Huang; Deke Jiang; Rong Na; Zhaoqing Yin; Jingjing Zhang; Haitao Chen

doi:10.1016/j.aohep.2024.101750

Metabolic dysfunction-associated steatotic liver disease and risk of four intrahepatic and extrahepatic diseases

Ann Hepatol. 2024 Dec 4;30(1):101750. doi: 10.1016/j.aohep.2024.101750. Online ahead of print.

Authors

Yiyuan Xiao¹, Sihua Xu², Wenyan Hu³, Jiapeng Huang⁴, Deke Jiang⁵, Rong Na⁶, Zhaoqing Yin⁷, Jingjing Zhang⁸, Haitao Chen⁹

Affiliations

¹ School of Public Health (Shenzhen), Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, Guangdong, China; Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, Guangdong, China. Electronic address: [email protected].
² School of Public Health (Shenzhen), Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, Guangdong, China; Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, Guangdong, China. Electronic address: [email protected].
³ School of Public Health (Shenzhen), Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, Guangdong, China; Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, Guangdong, China. Electronic address: [email protected].
⁴ Department of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China. Electronic address: [email protected].
⁵ State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institutes of Liver Diseases Research of Guangdong Province, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong, China. Electronic address: [email protected].
⁶ Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam Hong Kong SAR, Hong Kong, China (Hong Kong). Electronic address: [email protected].
⁷ Department of Pediatric, Dehong People Hospital, 13 Yonghan Street, Mangshi, Dehong Dai and Jingpo Autonomous Prefecture, Yunnan, China. Electronic address: [email protected].
⁸ School of Public Health (Shenzhen), Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, Guangdong, China; Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, Guangdong, China. Electronic address: [email protected].
⁹ School of Public Health (Shenzhen), Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, Guangdong, China; Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, Guangdong, China. Electronic address: [email protected].

PMID: 39638041
DOI: 10.1016/j.aohep.2024.101750

Abstract

Introduction and objectives: Recently, Delphi consensus proposed an overarching term steatotic liver disease (SLD), with various subcategories such as MASLD, MetALD and ALD. Our aim was to investigate the association between MASLD/MetALD/ALD and four intrahepatic and extrahepatic diseases (liver diseases, renal diseases, cardiovascular diseases, and cancers) in the UK Biobank cohort.

Patients and methods: By defining hepatic steatosis as image-derived phenotype (IDP)-PDFF >5.21%, we used data from the UK Biobank to diagnose MASLD/ MetALD/ALD. The odd ratio (OR) and the hazard ratio (HR) were calculated using the logistic regression modals and Cox regression models, respectively.

Results: Among 39,230 eligible individuals, 6,865 MASLD subjects, 2,379 MetALD subjects and 884 ALD subjects were diagnosed. The last follow-up time was October 13, 2023. Consistent with the logistic analyses, MASLD/MetALD/ALD were significantly associated with a higher risk of liver diseases (HR=3.04 [95%CI:2.60-3.56], HR = 2.69 [95% CI: 2.12-3.42] and HR =3.99 [95%CI:2.92-5.45], respectively). Subjects with MASLD also had an increased higher risk of renal diseases (HR = 1.40 [95%CI:1.20-1.64]) and subjects with ALD had an increased higher risk of cancers (HR = 1.36 [95%CI:1.15-1.60]).

Conclusion: It is the first study to report the association between MASLD, MetALD, ALD and common intrahepatic and extrahepatic diseases based on magnetic resonance imaging data-PDFF. We found that MASLD, MetALD and ALD were risk factors for liver diseases. Meanwhile, MASLD was also a risk factor for renal diseases and ALD was a risk factor for cancers.

Keywords: Intrahepatic and extrahepatic diseases; MASLD/MetALD/ALD; NAFLD; Risk factor.