Feasibility of Fish Oil Supplementation on Headache Symptoms and Blood Lipids in Migraine Patients

Brain Behav. 2024 Dec;14(12):e70149. doi: 10.1002/brb3.70149.

Abstract

Objectives: Migraine is a chronic, recurring, and disabling disease. Fish oil intervention was used to investigate its effects on headache symptoms and blood lipids of migraine patients.

Design: All subjects were collected at the Kuang Tian General Hospital from March 2020 to May 2021. Experimental group subjects took 1 g/time of fish oil (including EPA 900 mg/tablet) after breakfast and dinner. Placebo group subjects took 100% soybean oil twice daily. Before and after the test, the migraine improvement questionnaire was used to analyze headaches during attacks, dietary intake, and headache triggers.

Results: The average age of the 47 subjects in this study was 40.3 ± 9.2 years old, the body mass index (BMI) was 24.3 ± 6.0 kg/m2. At Week 12, subjects in the fish oil group were significantly improved relative to the control group (p < 0.05). Blood lipid indexes TC, LDL-C, and TG were reduced, and the frequency, duration, and pain degree of migraine.

Conclusion: Fish oil may be used as an adjunctive therapeutic food for relieving migraine attack symptoms and blood lipids.

Keywords: blood lipid; fish oil; headache symptom; migraine.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Dietary Supplements*
  • Eicosapentaenoic Acid / administration & dosage
  • Eicosapentaenoic Acid / blood
  • Eicosapentaenoic Acid / pharmacology
  • Feasibility Studies*
  • Female
  • Fish Oils* / administration & dosage
  • Headache / blood
  • Headache / drug therapy
  • Humans
  • Lipids / blood
  • Male
  • Middle Aged
  • Migraine Disorders* / blood
  • Migraine Disorders* / diet therapy
  • Migraine Disorders* / drug therapy

Substances

  • Fish Oils
  • Lipids
  • Eicosapentaenoic Acid