Abstract
基于替代标志物的子宫内膜癌分子分型已在临床实践中得到广泛推广应用。尽管大部分子宫内膜癌病例能够通过单一的分子特征进行分类，但仍有3.0%~11.4%的子宫内膜癌表现出复杂的“多重分子特征”，涵盖了POLE基因突变、TP53基因突变和错配修复缺陷等多重组合方式。目前，针对这些具有多重分子特征的子宫内膜癌，其分类标准和治疗策略仍存在较大的争议。本文旨在对这些具有“多重分子特征”子宫内膜癌的分子机制进行全面综述，以期深化对这一特殊类型子宫内膜癌的理解和认识，从而为临床决策提供更为精准和全面的依据。.
MeSH terms
-
Biomarkers, Tumor / genetics
-
Biomarkers, Tumor / metabolism
-
Carcinoma, Endometrioid / classification
-
Carcinoma, Endometrioid / genetics
-
Carcinoma, Endometrioid / metabolism
-
Carcinoma, Endometrioid / pathology
-
DNA Mismatch Repair*
-
DNA Polymerase II / genetics
-
DNA Polymerase II / metabolism
-
Endometrial Neoplasms* / classification
-
Endometrial Neoplasms* / genetics
-
Endometrial Neoplasms* / metabolism
-
Endometrial Neoplasms* / pathology
-
Female
-
Humans
-
Microsatellite Instability
-
Mutation*
-
Poly-ADP-Ribose Binding Proteins* / genetics
-
Poly-ADP-Ribose Binding Proteins* / metabolism
-
Tumor Suppressor Protein p53* / genetics
-
Tumor Suppressor Protein p53* / metabolism
Substances
-
Tumor Suppressor Protein p53
-
Poly-ADP-Ribose Binding Proteins
-
POLE protein, human
-
DNA Polymerase II
-
TP53 protein, human
-
Biomarkers, Tumor