Unveiling the biological functions and therapeutic potentials of LONP1 in the ovary

Trends Mol Med. 2024 Dec 7:S1471-4914(24)00311-3. doi: 10.1016/j.molmed.2024.11.010. Online ahead of print.

Abstract

Recent research highlights that Lon protease 1 (LONP1) regulates steroidogenesis in the ovary and plays a role in oocyte development and quality control. Dysregulation of LONP1 has been observed in polycystic ovary syndrome and ovarian aging. This forum article explores the role of LONP1 in the ovary and its therapeutic potential.

Keywords: Lon protease 1; mitochondria; ovarian aging; polycystic ovary syndrome.