A crosstalk between autophagy and apoptosis in intracerebral hemorrhage

Moyan Wang; Xin Chen; Shuangyang Li; Lingxue Wang; Hongmei Tang; Yuting Pu; Dechou Zhang; Bangjiang Fang; Xue Bai

doi:10.3389/fncel.2024.1445919

A crosstalk between autophagy and apoptosis in intracerebral hemorrhage

Front Cell Neurosci. 2024 Nov 21:18:1445919. doi: 10.3389/fncel.2024.1445919. eCollection 2024.

Authors

Moyan Wang^#¹, Xin Chen^#¹, Shuangyang Li^#¹, Lingxue Wang¹, Hongmei Tang¹, Yuting Pu¹, Dechou Zhang^{1

2}, Bangjiang Fang^{1

3}, Xue Bai^{1

2}

Affiliations

¹ Department of Neurology, National Traditional Chinese Medicine Clinical Research Base, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
² Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou, China.
³ Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

^# Contributed equally.

Abstract

Intracerebral hemorrhage (ICH) is a severe condition that devastatingly harms human health and poses a financial burden on families and society. Bcl-2 Associated X-protein (Bax) and B-cell lymphoma 2 (Bcl-2) are two classic apoptotic markers post-ICH. Beclin 1 offers a competitive architecture with that of Bax, both playing a vital role in autophagy. However, the interaction between Beclin 1 and Bcl-2/Bax has not been conjunctively analyzed. This review aims to examine the crosstalk between autophagy and apoptosis in ICH by focusing on the interaction and balance of Beclin 1, Bax, and Bcl-2. We also explored the therapeutic potential of Western conventional medicine and traditional Chinese medicine (TCM) in ICH via controlling the crosstalk between autophagy and apoptosis.

Keywords: Bax; Bcl-2; apoptosis; autophagy; cerebral hemorrhage.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTD-C-202207), Sichuan Science and Technology Program (2022YFS0613), Luzhou Science and Technology Program (2020-SYF-30), and Program of Southwest Medical University (2023ZYYJ01, 2023ZYYJ09; 2020XYLH-018,029).