Ring opening of epoxides: a facile approach towards the synthesis of polyketides and related stereoenriched natural products: a review

Epoxides are significant heterocycles in the structural makeup of a variety of natural products. Their ring-opening reactions have emerged as a versatile and efficient strategies for synthesizing a variety of functionalized molecules. Such reactions have been extensively applied towards the preparation of complex naturally occurring products. The focus on epoxide ring-opening reactions within the scientific community has been increased, influenced by the goal to understand the synthesis of compounds that are important for their biological and structural significance. In this article, we have provided a concise account on the applications of epoxide's ring cleavage towards the syntheses of polyketides and related naturally occurring compounds, documented since last decade (2014-2023).