A Polygenic Predictor of Baseline QTc is Associated With Sotalol-Induced QT Prolongation

Affiliations

• ¹ Department of Medicine, Division of Cardiovascular Medicine (M.C.L., G.D., J.-E.S., D.M.R.), Vanderbilt University Medical Center, Nashville, TN.
• ² IRD, Sorbonne Université, Unité de Modélisation Mathématique et Informatique des Systèmes Complexes, UMMISCO, Bondy, France (E.P.).
• ³ Nutrition et Obesities, Systemic Approaches, NutriOmique (E.P.), INSERM, Sorbonne Université, Paris, France.
• ⁴ AP-HP, Hôpital Pitié-Salpêtrière, and Institute for Cardiometabolism and Nutrition (C.P.), INSERM, Sorbonne Université, Paris, France.
• ⁵ Pharmacology Department (C.F.-B., J.-E.S.), INSERM, Sorbonne Université, Paris, France.
• ⁶ Departments of Pharmacology and Biomedical Informatics (D.M.R.), Vanderbilt University Medical Center, Nashville, TN.