Corneal Endothelial Cell Morphology in Eyes With Down Syndrome

Hiroshi Okubo; Chie Sotozono; Shigeru Kinoshita

doi:10.1097/ICO.0000000000003773

Corneal Endothelial Cell Morphology in Eyes With Down Syndrome

Cornea. 2024 Dec 10. doi: 10.1097/ICO.0000000000003773. Online ahead of print.

Authors

Hiroshi Okubo^{1

2}, Chie Sotozono², Shigeru Kinoshita³

Affiliations

¹ Department of Ophthalmology, Kyoto City Hospital Organization, Kyoto, Japan.
² Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; and.
³ Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

PMID: 39655763
DOI: 10.1097/ICO.0000000000003773

Abstract

Purpose: To explore the morphological characteristics of corneal endothelial cells in eyes with Down syndrome.

Methods: We conducted a comparative analysis of corneal endothelial cell density, coefficient of variation, hexagonal cell appearance rate, and corneal thickness using specular microscopy. Our study included 21 eyes of 11 patients with Down syndrome and 37 eyes of 19 control subjects.

Results: In all eyes with Down syndrome, corneal endothelial cell density exceeded 2000 cells/mm2, and no abnormalities in cell morphology or significant differences from the control group were observed across all parameters.

Conclusions: The structure and function of corneal endothelial cells in eyes with Down syndrome were within the normal range, even in the presence of chromosomal abnormalities of 21-trisomy in somatic cells.