Protection from COVID-19 vaccination and prior SARS-CoV-2 infection among children aged 6 months - 4 years, United States, September 2022-April 2023

Leora R Feldstein; Jasmine Ruffin; Ryan Wiegand; Lauren Grant; Tara M Babu; Melissa Briggs-Hagen; Jefferey L Burgess; Alberto J Caban-Martinez; Helen Y Chu; Katherine D Ellingson; Janet A Englund; Kurt T Hegmann; Zuha Jeddy; Jennifer Kuntz; Adam S Lauring; Karen Lutrick; Emily T Martin; Clare Mathenge; Jennifer Meece; Claire M Midgley; Arnold S Monto; Allison L Naleway; Gabriella Newes-Adeyi; Leah Odame-Bamfo; Lauren Ew Olsho; Andrew L Phillips; Ramona P Rai; Sharon Saydah; Ning Smith; Harmony Tyner; Molly Vaughan; Ana A Weil; Sarang K Yoon; Amadea Britton; Manjusha Gaglani

doi:10.1093/jpids/piae121

Protection from COVID-19 vaccination and prior SARS-CoV-2 infection among children aged 6 months - 4 years, United States, September 2022-April 2023

J Pediatric Infect Dis Soc. 2024 Dec 5:piae121. doi: 10.1093/jpids/piae121. Online ahead of print.

Authors

Leora R Feldstein¹, Jasmine Ruffin¹, Ryan Wiegand¹, Lauren Grant¹, Tara M Babu², Melissa Briggs-Hagen¹, Jefferey L Burgess³, Alberto J Caban-Martinez⁴, Helen Y Chu², Katherine D Ellingson³, Janet A Englund⁵, Kurt T Hegmann⁶, Zuha Jeddy⁷, Jennifer Kuntz⁸, Adam S Lauring⁹, Karen Lutrick³, Emily T Martin¹⁰, Clare Mathenge¹¹, Jennifer Meece¹², Claire M Midgley¹, Arnold S Monto¹⁰, Allison L Naleway⁸, Gabriella Newes-Adeyi⁷, Leah Odame-Bamfo¹¹, Lauren Ew Olsho⁷, Andrew L Phillips⁶, Ramona P Rai⁷, Sharon Saydah¹, Ning Smith⁸, Harmony Tyner¹³, Molly Vaughan⁷, Ana A Weil², Sarang K Yoon⁶, Amadea Britton¹, Manjusha Gaglani^{14

15}

Affiliations

¹ Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
³ University of Arizona, Tucson, Arizona, USA.
⁴ Department of Public Health Science, University of Miami, Miami, Florida, USA.
⁵ Children's Research Institute, Seattle, Washington, USA.
⁶ University of Utah Health, Salt Lake City, Utah, USA.
⁷ Abt Associates Inc., Rockville, Maryland, USA.
⁸ Kaiser Permanente Center for Health Research, Portland, Oregon, USA.
⁹ Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
¹⁰ Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
¹¹ Baylor Scott and White Health, Temple, Texas,USA.
¹² Marshfield Clinic Research Institute, Marshfield, Wisconsin USA.
¹³ St. Luke's Regional Health Care System, Duluth, Minnesota, USA.
¹⁴ Baylor Scott and White Health, Temple, Texas, USA.
¹⁵ Baylor College of Medicine - Temple and Texas A&M University College of Medicine, Temple, Texas, USA.

PMID: 39656907
DOI: 10.1093/jpids/piae121

Abstract

To understand how COVID-19 vaccines impact infection risk in children <5 years, we assessed risk of SARS-CoV-2 infection from Sept 2022-April 2023 in three cohort studies. There was no difference in risk by vaccination status. While vaccines reduce severe disease, they may not reduce SARS-CoV-2 infections in young children.

Keywords: COVID-19; SARS-CoV-2; children; prior infection; vaccination.

Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society 2024. This work is written by (a) US Government employee(s) and is in the public domain in the US.