A study of changes in hematologic parameters in patients with migraine

Jiaonan Wu; Lulan Fu; Ziru Deng; Hanli Li; Linyan Zhong; Rupan Gao; Wei Gui

doi:10.1093/cei/uxae113

A study of changes in hematologic parameters in patients with migraine

Clin Exp Immunol. 2024 Dec 11:uxae113. doi: 10.1093/cei/uxae113. Online ahead of print.

Authors

Jiaonan Wu¹, Lulan Fu¹, Ziru Deng², Hanli Li³, Linyan Zhong⁴, Rupan Gao⁵, Wei Gui¹

Affiliations

¹ Department of Neurology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
² Department of Neurology, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
³ Department of Clinical Medicine, Anhui Medical College, Hefei,230601, China.
⁴ Ultrasonic chamber, Chengdu East District Hospital, Chengdu, 610011, China.
⁵ Department of Hematology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.

PMID: 39660838
DOI: 10.1093/cei/uxae113

Abstract

Introduction: To evaluate the characteristics of hematological parameters and peripheral inflammatory markers in migraine, including chronic migraine (CM) and episodic migraine (EM), and to explore their underlying mechanisms.

Method: A total of 88 subjects were enrolled, 58 with migraine (28 with chronic migraine and 30 with episodic migraine) and 30 healthy controls. All subjects were matched for age, gender and body mass index (BMI), and peripheral blood was collected. Hematological parameters and peripheral inflammatory markers (PIMs) were compared between migraineurs and healthy controls. The patients underwent hematological laboratory testing and calculated the PIMs. PIMs included neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), neutrophil/monocyte ratio (NMR), platelet/lymphocyte ratio (PLR), and platelet/monocyte ratio (PMR) ratio.

Result: Monocyte counts in migraine patients were significantly lower compared to healthy controls, while LMR and PMR were significantly higher. Statistically significant differences were observed in monocyte counts, LMR, and PMR among the three groups of CM, EM and HC patients. Post hoc Bonferroni t-test showed that monocyte counts were significantly lower in the EM group compared to the HC group, while LMR and PMR were significantly higher. Comparison between the EM and CM groups showed that LMR was significantly higher in the EM group. Differences in monocyte counts, LMR and PMR between the CM and HC groups were not statistically significant. Receiver operating characteristic (ROC) curve analysis indicated that the area under the curve (AUC) for the diagnosing migraine using the combination of Mon, LMR and PMR was 0.707, and the AUC for the diagnosis of EM was 0.758. The AUC value of PMR for diagnosing CM was 0.669, while the AUC for the combination of LMR and PLR in distinguishing CM and EM was 0.705.

Conclusion: Our findings indicate that migraine and its subtypes exhibit abnormalities in monocyte counts and PIMs, which possess diagnostic predictive value for differentiating migraine and its subtypes. This suggests that systemic inflammation may play a role in the pathogenesis of migraine.

Keywords: PIMs; chronic migraine; episodic migraine; migraine.

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