T-switch-ing TCR specificity

Immunity. 2024 Dec 10;57(12):2717-2719. doi: 10.1016/j.immuni.2024.11.014.

Abstract

Central tolerance restricts T cells that target self-antigens. In this issue of Immunity, Abdelfattah et al.1 describe a method to generate self-reactive T cell receptors (TCRs) by directed evolution of non-autoreactive TCRs to recognize self-antigen peptides and demonstrate potential for T cells engineered with such receptors in immunotherapy.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autoantigens / immunology
  • Humans
  • Receptors, Antigen, T-Cell* / immunology
  • Receptors, Antigen, T-Cell* / metabolism
  • T-Cell Antigen Receptor Specificity / immunology
  • T-Lymphocytes / immunology

Substances

  • Receptors, Antigen, T-Cell
  • Autoantigens