Hemophilia C is a rare bleeding disorder, and such patients with chronic kidney disease are at risk for bleeding during kidney transplant surgery. Kidney transplant patients with hemophilia C can be managed meticulously through a protocol to maintain a coagulation profile in the reference range. Here, we present a case study that focused on a treatment protocol for a patient with chronic kidney disease and hemophilia C who underwent kidney transplant surgery. Patients with hemophilia C who develop chronic kidney disease stage 5 can safely undergo a kidney transplant or any other major surgery using the defined protocol.